Gene

gli3

ID

ZDB-GENE-041111-162

Name

GLI family zinc finger 3

Symbol

gli3 Nomenclature History

Previous Names

fpr (1)
im:7142603

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within generation of neurons and regulation of neurogenesis. Is active in chromatin. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 16 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7142603 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Devine et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gli3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Greig cephalopolysyndactyly syndrome	Alliance	Greig cephalopolysyndactyly syndrome	175700
Pallister-Hall syndrome	Alliance	Pallister-Hall syndrome	146510
polydactyly	Alliance	Polydactyly, postaxial, types A1 and B	174200
polydactyly	Alliance	Polydactyly, preaxial, type IV	174700
preaxial polydactyly type IV	Alliance	Polydactyly, preaxial, type IV	174700