Gene

met

ID

ZDB-GENE-041014-1

Name

MET proto-oncogene, receptor tyrosine kinase

Symbol

met Nomenclature History

Previous Names

c-met (1)
cmet (1)
don

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable hepatocyte growth factor receptor activity. Acts upstream of or within several processes, including exocrine pancreas development; nervous system development; and pectoral fin development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7153684 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 29 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With met Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 97	Alliance	?Deafness, autosomal recessive 97	616705
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, childhood type, somatic	114550
papillary renal cell carcinoma	Alliance	Renal cell carcinoma, papillary, 1, familial and somatic	605074
		?Arthrogryposis, distal, type 11	620019
		{Osteofibrous dysplasia, susceptibility to}	607278

Associated With met Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001627	Sema domain
Domain	IPR002909	IPT domain
Domain	IPR016201	PSI domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR016244	Tyrosine-protein kinase, HGF/MSP receptor
Family	IPR031148	Plexin family
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036352	Sema domain superfamily
Repeat	IPR002165	Plexin repeat