Gene
ercc8
- ID
- ZDB-GENE-041010-60
- Name
- excision repair cross-complementation group 8
- Symbol
- ercc8 Nomenclature History
- Previous Names
-
- CSA (1)
- zgc:103550
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in cellular protein metabolic process; positive regulation of DNA repair; and transcription-coupled nucleotide-excision repair. Predicted to localize to Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103550 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cockayne syndrome A | Alliance | Cockayne syndrome, type A | 216400 |
| UV-sensitive syndrome | Alliance | UV-sensitive syndrome 2 | 614621 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR042238 | DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1 | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5XJ81
|
400 |
Interactions and Pathways
No data available
Plasmids
No data available