Gene
acox1
- ID
- ZDB-GENE-041010-219
- Name
- acyl-CoA oxidase 1, palmitoyl
- Symbol
- acox1 Nomenclature History
- Previous Names
-
- wu:fb59h12
- zgc:114033
- zgc:92584
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have fatty acid binding activity; flavin adenine dinucleotide binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase; lipid homeostasis; and very long-chain fatty acid metabolic process. Predicted to localize to peroxisome. Human ortholog(s) of this gene implicated in peroxisomal acyl-CoA oxidase deficiency. Is expressed in several structures, including female organism; heart; immature eye; liver; and pleuroperitoneal region. Orthologous to human ACOX1 (acyl-CoA oxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92584 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mitchell syndrome | Alliance | Mitchell syndrome | 618960 |
| peroxisomal acyl-CoA oxidase deficiency | Alliance | Peroxisomal acyl-CoA oxidase deficiency | 264470 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002655 | Acyl-CoA oxidase, C-terminal |
| Domain | IPR029320 | Acyl-coenzyme A oxidase, N-terminal |
| Family | IPR012258 | Acyl-CoA oxidase |
| Family | IPR034171 | Peroxisomal acyl-coenzyme A oxidase |
| Homologous_superfamily | IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily |
| Homologous_superfamily | IPR036250 | Acyl-CoA dehydrogenase-like, C-terminal |
| Homologous_superfamily | IPR037069 | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily |
| Homologous_superfamily | IPR046373 | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily |
Domain Details Per Protein
| Protein | Length | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase | Acyl-CoA oxidase, C-terminal | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily | Acyl-coenzyme A oxidase, N-terminal | Peroxisomal acyl-coenzyme A oxidase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R071
|
660 | ||||||||
|
UniProtKB:Q5XIZ4
|
660 |
Interactions and Pathways
No data available
Plasmids
No data available