Gene
gss
- ID
- ZDB-GENE-041010-208
- Name
- glutathione synthetase
- Symbol
- gss Nomenclature History
- Previous Names
-
- sb:cb814
- zgc:101574
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in head; head kidney; lens; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb814 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 6 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 6, glutatione synthetase deficient | 231900 |
| glutatione synthetase deficiency with 5-oxoprolinuria | Alliance | Glutathione synthetase deficiency | 266130 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004887 | Glutathione synthase, substrate-binding domain |
| Family | IPR005615 | Glutathione synthase |
| Homologous_superfamily | IPR014042 | Glutathione synthase, alpha-helical |
| Homologous_superfamily | IPR014049 | Glutathione synthase, N-terminal, eukaryotic |
| Homologous_superfamily | IPR014709 | Glutathione synthase, C-terminal, eukaryotic |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
| Homologous_superfamily | IPR037013 | Glutathione synthase, substrate-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Glutathione synthase | Glutathione synthase, alpha-helical | Glutathione synthase, C-terminal, eukaryotic | Glutathione synthase, N-terminal, eukaryotic | Glutathione synthase, substrate-binding domain | Glutathione synthase, substrate-binding domain superfamily | Pre-ATP-grasp domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5XJT8
|
475 | |||||||
|
UniProtKB:F1RC64
|
475 |
Interactions and Pathways
No data available
Plasmids
No data available