Gene
gss
- ID
- ZDB-GENE-041010-208
- Name
- glutathione synthetase
- Symbol
- gss Nomenclature History
- Previous Names
-
- sb:cb814
- zgc:101574
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in head kidney; lens; pronephric duct; and solid lens vesicle. Orthologous to human GSS (glutathione synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb814 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 6 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 6, glutatione synthetase deficient | 231900 |
| glutatione synthetase deficiency with 5-oxoprolinuria | Alliance | Glutathione synthetase deficiency | 266130 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004887 | Glutathione synthase, substrate-binding domain |
| Family | IPR005615 | Glutathione synthase |
| Homologous_superfamily | IPR014042 | Glutathione synthase, alpha-helical |
| Homologous_superfamily | IPR014049 | Glutathione synthase, N-terminal, eukaryotic |
| Homologous_superfamily | IPR014709 | Glutathione synthase, C-terminal, eukaryotic |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
| Homologous_superfamily | IPR037013 | Glutathione synthase, substrate-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Glutathione synthase | Glutathione synthase, alpha-helical | Glutathione synthase, C-terminal, eukaryotic | Glutathione synthase, N-terminal, eukaryotic | Glutathione synthase, substrate-binding domain | Glutathione synthase, substrate-binding domain superfamily | Pre-ATP-grasp domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5XJT8
|
475 | |||||||
|
UniProtKB:F1RC64
|
475 |
Interactions and Pathways
No data available
Plasmids
No data available