Gene

amt

ID

ZDB-GENE-041010-114

Name

aminomethyltransferase

Symbol

amt Nomenclature History

Previous Names

fc31f04
wu:fc31f04
wu:fd44b12
wu:fd54h12
zgc:103483
zgc:109741

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human AMT (aminomethyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103483 (10 images)
IMAGE:7157160 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With amt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
glycine encephalopathy 2	Alliance	Glycine encephalopathy 2	620398

Associated With amt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006222	Aminomethyltransferase, folate-binding domain
Family	IPR006223	Glycine cleavage system T protein
Family	IPR028896	Aminomethyltransferase-like
Homologous_superfamily	IPR027266	GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Homologous_superfamily	IPR029043	Glycine cleavage T-protein/YgfZ, C-terminal