Gene
cul4b
- ID
- ZDB-GENE-041008-208
- Name
- cullin 4B
- Symbol
- cul4b Nomenclature History
- Previous Names
-
- im:7140950
- im:7150765
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and cellular response to DNA damage stimulus. Predicted to localize to Cul4-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked intellectual disability Cabezas type | Alliance | Intellectual developmental disorder, X-linked syndromic, Cabezas type | 300354 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016157 | Cullin, conserved site |
| Domain | IPR001373 | Cullin, N-terminal |
| Domain | IPR016158 | Cullin homology domain |
| Domain | IPR019559 | Cullin protein, neddylation domain |
| Family | IPR045093 | Cullin |
| Homologous_superfamily | IPR016159 | Cullin repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036317 | Cullin homology domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cullin | Cullin, conserved site | Cullin homology domain | Cullin homology domain superfamily | Cullin, N-terminal | Cullin protein, neddylation domain | Cullin repeat-like-containing domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W428
|
864 |
Interactions and Pathways
No data available
Plasmids
No data available