Gene

nop10

ID

ZDB-GENE-041007-4

Name

NOP10 ribonucleoprotein homolog (yeast)

Symbol

nop10 Nomenclature History

Previous Names

nola3
zgc:109956

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have box H/ACA snoRNA binding activity and telomerase RNA binding activity. Involved in primitive hemopoiesis and rRNA processing. Predicted to localize to box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109956 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nop10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive dyskeratosis congenita 1	Alliance	?Dyskeratosis congenita, autosomal recessive 1	224230
		?Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2	620425
		?Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9	620400

Associated With nop10 Via Experimental Models

Human Disease	Fish	Conditions	Citations
dyskeratosis congenita	nop10^{hi2578Tg/hi2578Tg}	standard conditions	Pereboom et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007264	H/ACA ribonucleoprotein complex, subunit Nop10
Homologous_superfamily	IPR036756	H/ACA ribonucleoprotein complex, subunit Nop10 superfamily