Gene
ccn6
- ID
- ZDB-GENE-041001-86
- Name
- cellular communication network factor 6
- Symbol
- ccn6 Nomenclature History
- Previous Names
-
- si:dkey-119m7.6
- wisp3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including BMP signaling pathway; cartilage development; and negative regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in otic vesicle; skeletal muscle; swim bladder; and ventricular zone. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| progressive pseudorheumatoid arthropathy of childhood | Alliance | Progressive pseudorheumatoid dysplasia | 208230 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR006208 | Glycoprotein hormone subunit beta |
| Domain | IPR043973 | CCN, TSP1 domain |
| Family | IPR050941 | Cellular Communication Network Factor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:D0E2W2
|
338 | |||||||||
|
UniProtKB:A0A8M6YUV4
|
331 |
Interactions and Pathways
No data available
Plasmids
No data available