Gene

map3k7

ID

ZDB-GENE-041001-135

Name

mitogen-activated protein kinase kinase kinase 7

Symbol

map3k7 Nomenclature History

Previous Names

si:ch211-225h9.1 (1)
tak1 (1)
zgc:110612 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within blood vessel morphogenesis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110612 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
frontometaphyseal dysplasia 2	Alliance	Frontometaphyseal dysplasia 2	617137
		Cardiospondylocarpofacial syndrome	157800

Associated With map3k7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Family	IPR049637	Mitogen-activated protein kinase kinase kinase 7
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase kinase kinase 7	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A8M3AT57 InterPro	578
UniProtKB:Q503G7 InterPro	544

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	map3k7-205 (1) Ensembl	Ensembl	871 nt	Select Tool ZFIN BLAST
mRNA	map3k7-201 (1) Ensembl	Ensembl	4,042 nt	Select Tool ZFIN BLAST
mRNA	map3k7-202 (1) Ensembl	Ensembl	870 nt	Select Tool ZFIN BLAST
mRNA	map3k7-203 (1) Ensembl	Ensembl	820 nt	Select Tool ZFIN BLAST
mRNA	map3k7-207 (1) Ensembl	Ensembl	4,689 nt	Select Tool ZFIN BLAST
ncRNA	map3k7-004 (1) Ensembl	Ensembl	909 nt	Select Tool ZFIN BLAST
ncRNA	map3k7-006 (1) Ensembl	Ensembl	915 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations