Gene

mthfd1l

ID

ZDB-GENE-041001-133

Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

Symbol

mthfd1l Nomenclature History

Previous Names

fk48e08
si:dkey-25e12.5
si:dkey-25e12.6
wu:fk48e08

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in 10-formyltetrahydrofolate biosynthetic process and purine nucleobase biosynthetic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Hsiao et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mthfd1l Human Ortholog

No data available

Associated With mthfd1l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020628	Formate-tetrahydrofolate ligase, FTHFS, conserved site
Domain	IPR020630	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain	IPR020631	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family	IPR000559	Formate-tetrahydrofolate ligase, FTHFS
Family	IPR000672	Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily
Homologous_superfamily	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Formate-tetrahydrofolate ligase, FTHFS	Formate-tetrahydrofolate ligase, FTHFS, conserved site	NAD(P)-binding domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Tetrahydrofolate dehydrogenase/cyclohydrolase	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
UniProtKB:F1QQ79 InterPro	978

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mthfd1l-201 (1) Ensembl	Ensembl	5,521 nt	Select Tool
mRNA	mthfd1l-202 (1) Ensembl	Ensembl	854 nt	Select Tool
mRNA	mthfd1l-205 (1) Ensembl	Ensembl	464 nt	Select Tool
mRNA	mthfd1l-206 (1) Ensembl	Ensembl	5,750 nt	Select Tool ZFIN BLAST
ncRNA	mthfd1l-003 (1) Ensembl	Ensembl	541 nt	Select Tool
ncRNA	mthfd1l-004 (1) Ensembl	Ensembl	766 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations