Gene
irf4b
- ID
- ZDB-GENE-041001-131
- Name
- interferon regulatory factor 4b
- Symbol
- irf4b Nomenclature History
- Previous Names
-
- si:dkey-25e12.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in immune system process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Is expressed in several structures, including axis; chordo neural hinge; muscle; nervous system; and pleuroperitoneal region. Orthologous to human IRF4 (interferon regulatory factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1640 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Skin/hair/eye pigmentation, variation in, 8] | 611724 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PTA5
|
433 |
Interactions and Pathways
No data available
Plasmids
No data available