Gene
cnot1
- ID
- ZDB-GENE-040915-1
- Name
- CCR4-NOT transcription complex, subunit 1
- Symbol
- cnot1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have estrogen receptor binding activity; molecular adaptor activity; and retinoic acid receptor binding activity. Involved in developmental growth. Predicted to localize to CCR4-NOT core complex and P-body. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141761 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 12 | Alliance | Holoprosencephaly 12, with or without pancreatic agenesis | 618500 |
| Vissers-Bodmer syndrome | Alliance | Vissers-Bodmer syndrome | 619033 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007196 | CCR4-Not complex component, Not1, C-terminal |
| Domain | IPR024557 | CCR4-NOT transcription complex subunit 1, domain 4 |
| Domain | IPR032191 | CCR4-NOT transcription complex subunit 1, CAF1-binding domain |
| Domain | IPR032193 | CCR4-NOT transcription complex subunit 1, TTP binding domain |
| Domain | IPR032194 | CCR4-NOT transcription complex subunit 1, HEAT repeat |
| Family | IPR040398 | CCR4-NOT transcription complex subunit 1 |
| Homologous_superfamily | IPR038535 | CCR4-NOT subunit 1, TTP binding domain superfamily |
Domain Details Per Protein
| Protein | Length | CCR4-Not complex component, Not1, C-terminal | CCR4-NOT subunit 1, TTP binding domain superfamily | CCR4-NOT transcription complex subunit 1 | CCR4-NOT transcription complex subunit 1, CAF1-binding domain | CCR4-NOT transcription complex subunit 1, domain 4 | CCR4-NOT transcription complex subunit 1, HEAT repeat | CCR4-NOT transcription complex subunit 1, TTP binding domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A1A5H6
|
2374 |
Interactions and Pathways
No data available
Plasmids
No data available