Gene
etfdh
- ID
- ZDB-GENE-040912-168
- Name
- electron transfer flavoprotein dehydrogenase
- Symbol
- etfdh Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and oxidoreductase activity, oxidizing metal ions with flavin as acceptor. Involved in respiratory electron transport chain. Predicted to localize to integral component of mitochondrial inner membrane. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from Song et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple acyl-CoA dehydrogenase deficiency | Alliance | Glutaric acidemia IIC | 231680 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| multiple acyl-CoA dehydrogenase deficiency | etfdhp6di/p6di | standard conditions | Song et al., 2009 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007859 | ETF-QO/FixX, C-terminal domain |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR049398 | ETF-QO/FixC, ubiquinone-binding |
| Family | IPR040156 | Electron transfer flavoprotein-ubiquinone oxidoreductase |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Electron transfer flavoprotein-ubiquinone oxidoreductase | ETF-QO/FixC, ubiquinone-binding | ETF-QO/FixX, C-terminal domain | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I16
|
617 |
Interactions and Pathways
No data available
Plasmids
No data available