Gene
rfc4
- ID
- ZDB-GENE-040824-3
- Name
- replication factor C (activator 1) 4
- Symbol
- rfc4 Nomenclature History
- Previous Names
-
- zgc:64030
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to contribute to DNA clamp loader activity. Involved in retina development in camera-type eye. Predicted to localize to DNA replication factor C complex and nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RFC4 (replication factor C subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64030 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Morimoto-Ryu-Malicdan neuromuscular syndrome | 621010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR013748 | Replication factor C, C-terminal |
| Domain | IPR047854 | Replication factor C, lid domain |
| Family | IPR050238 | DNA Replication and Repair Clamp Loader Complex |
| Homologous_superfamily | IPR008921 | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ATPase, AAA-type, core | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal | DNA Replication and Repair Clamp Loader Complex | P-loop containing nucleoside triphosphate hydrolase | Replication factor C, C-terminal | Replication factor C, lid domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRF4
|
358 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rfc4-205
(1)
|
Ensembl | 638 nt | ||
| mRNA |
rfc4-201
(1)
|
Ensembl | 609 nt | ||
| mRNA |
rfc4-202
(1)
|
Ensembl | 1,077 nt | ||
| mRNA |
rfc4-203
(1)
|
Ensembl | 809 nt | ||
| mRNA |
rfc4-204
(1)
|
Ensembl | 305 nt | ||
| mRNA |
rfc4-206
(1)
|
Ensembl | 811 nt | ||
| mRNA |
rfc4-207
(1)
|
Ensembl | 1,622 nt | ||
| mRNA |
rfc4-208
(1)
|
Ensembl | 441 nt |
Interactions and Pathways
No data available
Plasmids
No data available