Gene
ak1
- ID
- ZDB-GENE-040822-37
- Name
- adenylate kinase 1
- Symbol
- ak1 Nomenclature History
- Previous Names
-
- zgc:91930 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in ATP metabolic process; nucleoside phosphate metabolic process; and phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Is expressed in cephalic musculature; hypaxial myotome region; myotome; pectoral fin musculature; and somite. Orthologous to human AK1 (adenylate kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6899635 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemolytic anemia | Alliance | Anemia, congenital, nonspherocytic hemolytic, 3, adenylate kinase deficient | 612631 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033690 | Adenylate kinase, conserved site |
| Family | IPR000850 | Adenylate kinase/UMP-CMP kinase |
| Family | IPR006267 | Adenylate kinase, isozyme 1/5 |
| Family | IPR028582 | Adenylate kinase isoenzyme 1 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | Adenylate kinase, conserved site | Adenylate kinase isoenzyme 1 | Adenylate kinase, isozyme 1/5 | Adenylate kinase/UMP-CMP kinase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BGJ7
|
209 | |||||
|
UniProtKB:Q68EH2
|
194 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available