Gene

stat5b

ID

ZDB-GENE-040818-1

Name

signal transducer and activator of transcription 5b

Symbol

stat5b Nomenclature History

Previous Names

stat5.2

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; defense response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol and nucleus. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:113865 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Huang et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
growth hormone insensitivity syndrome with immune dysregulation 1	Alliance	Growth hormone insensitivity with immune dysregulation 1, autosomal recessive	245590
growth hormone insensitivity syndrome with immune dysregulation 2	Alliance	Growth hormone insensitivity with immune dysregulation 2, autosomal dominant	618985

Associated With stat5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR046994	STAT5a/5b, coiled-coil domain
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	p53-like transcription factor, DNA-binding domain superfamily	SH2 domain	SH2 domain superfamily	Signal transducer and activator of transcription, linker domain	STAT5a/5b, coiled-coil domain	STAT transcription factor, all-alpha domain	STAT transcription factor, coiled coil	STAT transcription factor, DNA-binding	STAT transcription factor, DNA-binding, N-terminal	STAT transcription factor, N-terminal domain superfamily	STAT transcription factor, protein interaction	Transcription factor STAT
UniProtKB:Q68SP2 InterPro	787

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	stat5b-201 (1) Ensembl	Ensembl	1,433 nt	Select Tool
mRNA	stat5b-202 (1) Ensembl	Ensembl	3,525 nt	Select Tool
mRNA	stat5b-203 (1) Ensembl	Ensembl	3,528 nt	Select Tool
mRNA	stat5b-204 (1) Ensembl	Ensembl	2,726 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations