Gene
atm
- ID
- ZDB-GENE-040809-1
- Name
- ATM serine/threonine kinase
- Symbol
- atm Nomenclature History
- Previous Names
-
- chunp9624
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Exhibits kinase activity. Involved in DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; ataxia telangiectasia; breast cancer; endometrial cancer; and pancreatic cancer. Is expressed in brain; immature eye; and post-vent region. Orthologous to human ATM (ATM serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Chen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia telangiectasia | Alliance | Ataxia-telangiectasia | 208900 |
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| Lymphoma, B-cell non-Hodgkin, somatic | |||
| Lymphoma, mantle cell, somatic | |||
| T-cell prolymphocytic leukemia, somatic |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ataxia telangiectasia | atmzf3863/zf3863 (TU) | standard conditions | Chen et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR014009 | PIK-related kinase |
| Domain | IPR021668 | Telomere-length maintenance and DNA damage repair |
| Domain | IPR044107 | ATM, catalytic domain |
| Family | IPR038980 | Serine/threonine-protein kinase ATM, plant |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | ATM, catalytic domain | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Serine/threonine-protein kinase ATM, plant | Telomere-length maintenance and DNA damage repair |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJB6
|
3091 |
Interactions and Pathways
Plasmids
No data available