Gene

ndufv1

ID

ZDB-GENE-040808-73

Name

NADH:ubiquinone oxidoreductase core subunit V1

Symbol

ndufv1 Nomenclature History

Previous Names

wu:fc01f01
wu:fc12f12
zgc:86620

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6892746 (1 image)
IMAGE:7157113 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndufv1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 4	Alliance	Mitochondrial complex I deficiency, nuclear type 4	618225

Associated With ndufv1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001949	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Domain	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Domain	IPR019575	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Family	IPR011537	NADH ubiquinone oxidoreductase, F subunit
Family	IPR050837	Complex I 51 kDa subunit
Homologous_superfamily	IPR037207	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Homologous_superfamily	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily