Gene

traf3

ID

ZDB-GENE-040801-257

Name

TNF receptor-associated factor 3

Symbol

traf3 Nomenclature History

Previous Names

zgc:92367 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have tumor necrosis factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activity. Involved in response to yeast. Predicted to localize to cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92367 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With traf3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{?Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 5}	614849

Associated With traf3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001293	Zinc finger, TRAF-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR002083	MATH/TRAF domain
Domain	IPR027128	TNF receptor-associated factor 3, C3HC3D-type RING zinc finger
Domain	IPR037304	TNF receptor-associated factor 3, MATH domain
Domain	IPR049342	TRAF1-6, MATH domain
Domain	IPR049440	TNF receptor-associated factor 3/5, RING domain
Family	IPR012227	TNF receptor-associated factor TRAF, metazoa
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type