Gene

c8a

ID

ZDB-GENE-040801-239

Name

complement component 8, alpha polypeptide

Symbol

c8a Nomenclature History

Previous Names

zgc:92465 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Is expressed in chondrocranium; cleithrum; and liver. Orthologous to human C8A (complement C8 alpha chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92465 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c8a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type I complement component 8 deficiency	Alliance	C8 deficiency, type I	613790

Associated With c8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Domain	IPR048831	Complement components C8A/B/C6, EGF-like domain
Family	IPR001862	Membrane attack complex component/perforin/complement C9
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat