Gene

p4ha1a

ID

ZDB-GENE-040724-91

Name

prolyl 4-hydroxylase, alpha polypeptide I a

Symbol

p4ha1a Nomenclature History

Previous Names

si:ch211-146f4.5

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to contribute to procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Hyvarinen et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With p4ha1a Human Ortholog

No data available

Associated With p4ha1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR013547	Prolyl 4-hydroxylase alpha-subunit, N-terminal
Domain	IPR044862	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Family	IPR045054	Prolyl 4-hydroxylase
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Oxoglutarate/iron-dependent dioxygenase domain	Prolyl 4-hydroxylase	Prolyl 4-hydroxylase, alpha subunit	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	Prolyl 4-hydroxylase alpha-subunit, N-terminal	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:F1QCL7 InterPro	541
UniProtKB:A0A0R4IQ20 InterPro	522
UniProtKB:E7FEB4 InterPro	541

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	p4ha1a-201 (1) Ensembl	Ensembl	1,626 nt	Select Tool
mRNA	p4ha1a-202 (1) Ensembl	Ensembl	2,239 nt	Select Tool
mRNA	p4ha1a-203 (1) Ensembl	Ensembl	1,569 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations