Gene

grhpra

ID

ZDB-GENE-040724-230

Name

glyoxylate reductase/hydroxypyruvate reductase a

Symbol

grhpra Nomenclature History

Previous Names

grhpr
si:ch211-240l14.3
zgc:109900

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152758 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grhpra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hyperoxaluria type 2	Alliance	Hyperoxaluria, primary, type II	260000

Associated With grhpra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR029753	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Family	IPR050223	D-isomer specific 2-hydroxyacid dehydrogenase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily