Gene
comtb
- ID
- ZDB-GENE-040724-164
- Name
- catechol-O-methyltransferase b
- Symbol
- comtb Nomenclature History
- Previous Names
-
- si:dkey-13a21.15 (1)
- zgc:162236
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to act upstream of or within catecholamine metabolic process and methylation. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; immune system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| panic disorder | Alliance | {Panic disorder, susceptibility to} | 167870 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Catechol O-methyltransferase, eukaryotic | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
|
UniProtKB:A4IG53
|
264 |
Interactions and Pathways
No data available
Plasmids
No data available