Gene

ctsl.1

ID

ZDB-GENE-040718-61

Name

cathepsin L.1

Symbol

ctsl.1 Nomenclature History

Previous Names

ctslc (1)
zgc:92089

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in gill; intestine; kidney; and testis.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Berg et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctsl.1 Human Ortholog

No data available

Associated With ctsl.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR013201	Cathepsin propeptide inhibitor domain (I29)
Domain	IPR039417	Papain-like cysteine endopeptidase
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Cathepsin propeptide inhibitor domain (I29)	Cysteine peptidase, asparagine active site	Cysteine peptidase, cysteine active site	Cysteine peptidase, histidine active site	Papain-like cysteine endopeptidase	Papain-like cysteine peptidase superfamily	Peptidase C1A	Peptidase C1A, papain C-terminal
UniProtKB:Q6DHT0 InterPro	334

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ctsl.1-202 (1) Ensembl	Ensembl	543 nt	Select Tool ZFIN BLAST
mRNA	ctsl.1-201 (1) Ensembl	Ensembl	1,434 nt	Select Tool ZFIN BLAST
mRNA	ctsl.1-204 (1) Ensembl	Ensembl	1,655 nt	Select Tool ZFIN BLAST
mRNA	ctsl.1-205 (1) Ensembl	Ensembl	1,817 nt	Select Tool ZFIN BLAST
ncRNA	ctsl.1-002 (1) Ensembl	Ensembl	642 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations