Gene

sec63

ID

ZDB-GENE-040718-328

Name

SEC63 homolog, protein translocation regulator

Symbol

sec63 Nomenclature History

Previous Names

zgc:92718

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and protein transmembrane transporter activity. Involved in endoplasmic reticulum unfolded protein response; liver development; and myelination. Predicted to localize to Sec62/Sec63 complex. Used to study fatty liver disease and polycystic liver disease. Human ortholog(s) of this gene implicated in polycystic liver disease. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151132 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sec63 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
polycystic liver disease 2	Alliance	Polycystic liver disease 2	617004

Associated With sec63 Via Experimental Models

Human Disease	Fish	Conditions	Citations
steatotic liver disease	sec63^st67/st67	standard conditions	(2)
polycystic liver disease	WT + MO1-sec63	standard conditions	Tietz Bogert et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001623	DnaJ domain
Domain	IPR004179	Sec63 domain
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036869	Chaperone J-domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain superfamily	Chaperone J-domain superfamily	DnaJ domain	Immunoglobulin E-set	Sec63 domain
UniProtKB:Q6DGY6 InterPro	751

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sec63-201 (1) Ensembl	Ensembl	4,207 nt	Select Tool ZFIN BLAST
mRNA	sec63-204 (1) Ensembl	Ensembl	4,207 nt	Select Tool ZFIN BLAST
ncRNA	sec63-002 (1) Ensembl	Ensembl	601 nt	Select Tool ZFIN BLAST
ncRNA	sec63-003 (1) Ensembl	Ensembl	753 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations