Gene

polr3k

ID

ZDB-GENE-040718-291

Name

polymerase (RNA) III (DNA directed) polypeptide K

Symbol

polr3k Nomenclature History

Previous Names

zgc:92774

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in nucleolus. Predicted to be part of RNA polymerase III complex. Is expressed in hematopoietic system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human POLR3K (RNA polymerase III subunit K).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92774 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With polr3k Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypomyelinating leukodystrophy 21	Alliance	Leukodystrophy, hypomyelinating, 21	619310

Associated With polr3k Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019761	DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Domain	IPR001222	Zinc finger, TFIIS-type
Domain	IPR001529	DNA-directed RNA polymerase, M/15kDa subunit
Domain	IPR034014	Pol III subunit C11, C-terminal zinc ribbon
Family	IPR012164	DNA-directed RNA polymerase subunit/transcription factor S