Gene
tk2
- ID
- ZDB-GENE-040718-243
- Name
- thymidine kinase 2
- Symbol
- tk2 Nomenclature History
- Previous Names
-
- zgc:100948
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have deoxynucleoside kinase activity. Predicted to be involved in nucleobase-containing compound metabolic process and phosphorylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Is expressed in exocrine pancreas and pectoral fin. Orthologous to human TK2 (thymidine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146682 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 | Alliance | ?Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 | 617069 |
| mitochondrial DNA depletion syndrome 2 | Alliance | Mitochondrial DNA depletion syndrome 2 (myopathic type) | 609560 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deoxynucleoside kinase domain | Deoxyribonucleoside Kinase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|
|
UniProtKB:A0A8M1N0Z5
|
268 |
Interactions and Pathways
No data available
Plasmids
No data available