Gene
rhocb
- ID
- ZDB-GENE-040718-144
- Name
- ras homolog family member Cb
- Symbol
- rhocb Nomenclature History
- Previous Names
-
- rhoad
- zgc:92350
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in dorsal aorta; intersegmental vessel; neural tube; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to several human genes including RHOA (ras homolog family member A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DHE8 | InterPro | 193 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Salas-Vidal et al., (2005) report orthology to human RHOA. Subsequent analysis suggests this zebrafish gene is the ortholog of human RHOC and mouse Rhoc based on amino acid identity and conserved location. A phylogenetic tree also suggests orthology to RHOC and Rhoc.