Gene
htra1a
- ID
- ZDB-GENE-040704-64
- Name
- HtrA serine peptidase 1a
- Symbol
- htra1a Nomenclature History
- Previous Names
-
- htra1
- zgc:92029
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable insulin-like growth factor binding activity; serine-type endopeptidase activity; and serine-type exopeptidase activity. Acts upstream of or within regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in cytosol and extracellular region. Predicted to be active in collagen-containing extracellular matrix. Is expressed in mesoderm and somite. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92029 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kim et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 7 | Alliance | {Macular degeneration, age-related, 7} | 610149 |
| age related macular degeneration 7 | Alliance | {Macular degeneration, age-related, neovascular type} | 610149 |
| CADASIL | Alliance | CARASIL syndrome | 600142 |
| CADASIL 2 | Alliance | Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 | 616779 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR002350 | Kazal domain |
| Family | IPR001940 | Peptidase S1C |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein, IGFBP | Kazal domain | Kazal domain superfamily | PDZ domain | PDZ superfamily | Peptidase S1C | Peptidase S1, PA clan |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6GMI0
|
479 | ||||||||
|
UniProtKB:B2GT42
|
479 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htra1a-201
(1)
|
Ensembl | 2,078 nt |
Interactions and Pathways
No data available
Plasmids
No data available