Gene

mthfd2

ID

ZDB-GENE-040704-20

Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Symbol

mthfd2 Nomenclature History

Previous Names

wu:fb38b11
wu:fe12e11
zgc:91891

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to localize to mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mthfd2 Human Ortholog

No data available

Associated With mthfd2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020867	Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Domain	IPR020630	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain	IPR020631	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family	IPR000672	Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily
Homologous_superfamily	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily