Gene
ren
- ID
- ZDB-GENE-040630-3
- Name
- renin
- Symbol
- ren Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in angiotensin maturation. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in artery; embryonic structure; intermediate mesoderm; and renal system. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial juvenile hyperuricemic nephropathy | Alliance | Tubulointerstitial kidney disease, autosomal dominant, 4 | 613092 |
| Renal tubular dysgenesis | 267430 | ||
| [Hyperproreninemia] |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Peptidase family A1 domain | Renin-like domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6YA65
|
395 |
Interactions and Pathways
No data available
Plasmids
No data available