Gene
tpm2
- ID
- ZDB-GENE-040625-114
- Name
- tropomyosin 2 (beta)
- Symbol
- tpm2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in striated muscle thin filament. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb836 (16 images)
- IMAGE:6892450 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 1A | 108120 |
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 2B4 | 108120 |
| nemaline myopathy 4 | Alliance | Congenital myopathy 23 | 609285 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|
|
UniProtKB:A0A8M2B1Q6
|
284 | ||
|
UniProtKB:A0A8M2B1K3
|
284 | ||
|
UniProtKB:A0A8M2B255
|
248 | ||
|
UniProtKB:A0A8M2B1Q8
|
248 | ||
|
UniProtKB:A0A8M2B2D1
|
248 | ||
|
UniProtKB:Q6IQD7
|
284 | ||
|
UniProtKB:A0A0R4IAL5
|
248 | ||
|
UniProtKB:A0A0R4IM99
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available