Gene
cacna1db
- ID
- ZDB-GENE-040525-3
- Name
- calcium channel, voltage-dependent, L type, alpha 1D subunit, b
- Symbol
- cacna1db Nomenclature History
- Previous Names
-
- cav1.3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in calcium ion import; membrane depolarization during action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in atrium and cardiac ventricle. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Liu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
congenital heart disease | AB + MO1-cacna1db | standard conditions | Liu et al., 2022 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR005821 | Ion transport domain |
Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
Domain | IPR031688 | Voltage-gated calcium channel subunit alpha, C-terminal |
Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
Family | IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit |
Family | IPR050599 | Voltage-dependent calcium channel alpha-1 subunit |
Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
Protein | Additional Resources | Length | Ion transport domain | Voltage-dependent calcium channel alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, L-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain | Voltage-gated calcium channel subunit alpha, C-terminal |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QJ57 | InterPro | 2087 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cacna1db-205
(1)
|
Ensembl | 802 nt |
Interactions and Pathways
No data available
Plasmids