Gene
wdr45
- ID
- ZDB-GENE-040426-990
- Name
- WD repeat domain 45
- Symbol
- wdr45 Nomenclature History
- Previous Names
-
- zgc:56345 (1)
- zgc:77017
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Predicted to act upstream of or within autophagy. Predicted to be located in phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56345 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodegeneration with brain iron accumulation 5 | Alliance | Neurodegeneration with brain iron accumulation 5 | 300894 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PROPPIN | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZUX3
|
358 | ||||
|
UniProtKB:A0A0R4I9F8
|
358 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available