Gene

rad54l

ID

ZDB-GENE-040426-968

Name

RAD54 like

Symbol

rad54l Nomenclature History

Previous Names

zgc:56289 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Exhibits DNA-dependent ATPase activity. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and reciprocal meiotic recombination. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56289 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad54l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	{Breast cancer, invasive ductal}	114480
non-Hodgkin lymphoma	Alliance	Lymphoma, non-Hodgkin, somatic	605027
		Adenocarcinoma, colonic, somatic

Associated With rad54l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000330	SNF2, N-terminal
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Family	IPR050496	SNF2/RAD54 Helicase and DNA Repair
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily