Gene

tab2

ID
ZDB-GENE-040426-933
Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Symbol
tab2 Nomenclature History
Previous Names
  • Tab2 (1)
  • map3k7ip2
  • zgc:77446
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; convergent extension involved in gastrulation; and heart development. Is expressed in bulbus arteriosus; dorsal aorta; and posterior cardinal vein. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thienpont et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Thienpont et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tab2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Congenital heart defects, nonsyndromic, 2 614980
Associated With tab2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR003892 Ubiquitin system component CUE
Domain IPR041911 TAB2/3, CUE domain
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Domain Details Per Protein
Protein Length TAB2/3, CUE domain Ubiquitin system component CUE Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily
UniProtKB:A0A8M6Z392 750
UniProtKB:Q5RFW2 711
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tab2-201 (1) Ensembl 3,969 nt
mRNA tab2-202 (1) Ensembl 486 nt
mRNA tab2-203 (1) Ensembl 1,120 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations