Gene

srp54

ID

ZDB-GENE-040426-818

Name

signal recognition particle 54

Symbol

srp54 Nomenclature History

Previous Names

zgc:55842 (1)
zgc:85713

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to contribute to GTPase activity. Acts upstream of or within exocrine pancreas development and neutrophil chemotaxis. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Used to study Shwachman-Diamond syndrome and neutropenia. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55842 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With srp54 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
severe congenital neutropenia 8	Alliance	Neutropenia, severe congenital, 8, autosomal dominant	618752

Associated With srp54 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Shwachman-Diamond syndrome	i114Tg; nz50Tg + MO1-srp54	standard conditions	Carapito et al., 2017
neutropenia	srp54^{sa11820/sa11820}	standard conditions	Schürch et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR004125	Signal recognition particle, SRP54 subunit, M-domain
Domain	IPR013822	Signal recognition particle SRP54, helical bundle
Family	IPR006325	Signal recognition particle, SRP54 subunit, eukaryotic
Family	IPR022941	Signal recognition particle, SRP54 subunit
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036891	Signal recognition particle, SRP54 subunit, M-domain superfamily
Homologous_superfamily	IPR042101	Signal recognition particle SRP54, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	P-loop containing nucleoside triphosphate hydrolase	Signal recognition particle SRP54, helical bundle	Signal recognition particle SRP54, N-terminal domain superfamily	Signal recognition particle, SRP54 subunit	Signal recognition particle, SRP54 subunit, eukaryotic	Signal recognition particle, SRP54 subunit, GTPase domain	Signal recognition particle, SRP54 subunit, M-domain	Signal recognition particle, SRP54 subunit, M-domain superfamily
UniProtKB:Q7ZVN5 InterPro	504

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	srp54-201 (1) Ensembl	Ensembl	2,315 nt	Select Tool ZFIN BLAST
mRNA	srp54-202 (1) Ensembl	Ensembl	1,543 nt	Select Tool ZFIN BLAST
ncRNA	srp54-002 (1) Ensembl	Ensembl	767 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations