Gene

vldlr

ID

ZDB-GENE-040426-803

Name

very low density lipoprotein receptor

Symbol

vldlr Nomenclature History

Previous Names

lr8 (1)
zgc:55792

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Is expressed in several structures, including axis; brain; pronephric duct; retinal ganglion cell layer; and spinal cord interneuron. Orthologous to human VLDLR (very low density lipoprotein receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55792 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vldlr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Alliance	Cerebellar hypoplasia, impaired intellectual development, and dysequilibrium syndrome 1	224050

Associated With vldlr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR050685	Low-density lipoprotein receptor
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Low-density lipoprotein receptor	NOTCH1 EGF-like calcium-binding domain	Six-bladed beta-propeller, TolB-like
UniProtKB:A0A8M2B1M8 InterPro	877
UniProtKB:A0A8M9PTE7 InterPro	856
UniProtKB:A0A8M2B226 InterPro	874
UniProtKB:E7FF13 InterPro	866
UniProtKB:A0A0R4IGN2 InterPro	863
UniProtKB:E9QBA5 InterPro	842

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vldlr-201 (1) Ensembl	Ensembl	3,751 nt	Select Tool ZFIN BLAST
mRNA	vldlr-203 (1) Ensembl	Ensembl	3,496 nt	Select Tool
mRNA	vldlr-205 (1) Ensembl	Ensembl	4,074 nt	Select Tool ZFIN BLAST
mRNA	vldlr-206 (1) Ensembl	Ensembl	4,053 nt	Select Tool ZFIN BLAST
mRNA	vldlr-207 (1) Ensembl	Ensembl	4,132 nt	Select Tool ZFIN BLAST
ncRNA	vldlr-002 (1) Ensembl	Ensembl	921 nt	Select Tool
ncRNA	vldlr-003 (1) Ensembl	Ensembl	752 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations