Gene

vldlr

ID

ZDB-GENE-040426-803

Name

very low density lipoprotein receptor

Symbol

vldlr Nomenclature History

Previous Names

lr8 (1)
zgc:55792

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Is expressed in several structures, including axis; brain; pronephric duct; retinal ganglion cell layer; and spinal cord interneuron. Orthologous to human VLDLR (very low density lipoprotein receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55792 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vldlr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Alliance	Cerebellar hypoplasia, impaired intellectual development, and dysequilibrium syndrome 1	224050

Associated With vldlr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR050685	Low-density lipoprotein receptor
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Low-density lipoprotein receptor	NOTCH1 EGF-like calcium-binding domain	Six-bladed beta-propeller, TolB-like
UniProtKB:A0A8M2B1M8 InterPro	877
UniProtKB:A0A8M9PTE7 InterPro	856
UniProtKB:A0A8M2B226 InterPro	874
UniProtKB:E7FF13 InterPro	866
UniProtKB:A0A0R4IGN2 InterPro	863
UniProtKB:E9QBA5 InterPro	842

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vldlr-201 (1) Ensembl	Ensembl	3,751 nt	Select Tool ZFIN BLAST
mRNA	vldlr-203 (1) Ensembl	Ensembl	3,496 nt	Select Tool ZFIN BLAST
mRNA	vldlr-205 (1) Ensembl	Ensembl	4,074 nt	Select Tool ZFIN BLAST
mRNA	vldlr-206 (1) Ensembl	Ensembl	4,053 nt	Select Tool ZFIN BLAST
mRNA	vldlr-207 (1) Ensembl	Ensembl	4,132 nt	Select Tool ZFIN BLAST
ncRNA	vldlr-002 (1) Ensembl	Ensembl	921 nt	Select Tool ZFIN BLAST
ncRNA	vldlr-003 (1) Ensembl	Ensembl	752 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations