Gene

lin28ab

ID

ZDB-GENE-040426-747

Name

lin-28 homolog Ab

Symbol

lin28ab Nomenclature History

Previous Names

lin28
lin28a
sb:cb650
zgc:55584 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and polysome binding activity. Involved in chordate embryonic development; negative regulation of gene expression; and regeneration. Predicted to localize to cytoplasmic ribonucleoprotein granule; nucleus; and polysome. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; neural plate; and neural tube. Orthologous to human LIN28A (lin-28 homolog A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

30 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb650 (33 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lin28ab Human Ortholog

No data available

Associated With lin28ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001878	Zinc finger, CCHC-type
Domain	IPR002059	Cold-shock protein Csp, DNA-binding
Domain	IPR011129	Cold-shock domain
Domain	IPR054081	Lin-28A-like, second zinc knuckle
Family	IPR051373	Lin-28 homolog RNA-binding protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR036875	Zinc finger, CCHC-type superfamily

Domain Details Per Protein

Protein	Length	Cold-shock domain	Cold-shock protein Csp, DNA-binding	Lin-28A-like, second zinc knuckle	Lin-28 homolog RNA-binding protein	Nucleic acid-binding, OB-fold	Zinc finger, CCHC-type	Zinc finger, CCHC-type superfamily
UniProtKB:Q803L0 InterPro	202
UniProtKB:A0A2R8Q8W5 InterPro	207
UniProtKB:I3IS11 InterPro	194

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lin28a-001 (1) Ensembl	Ensembl	2,020 nt	Select Tool ZFIN BLAST
mRNA	lin28a-203 (1) Ensembl	Ensembl	607 nt	Select Tool ZFIN BLAST
mRNA	lin28a-204 (1) Ensembl	Ensembl	547 nt	Select Tool ZFIN BLAST
mRNA	lin28a-206 (1) Ensembl	Ensembl	908 nt	Select Tool ZFIN BLAST
mRNA	lin28a-207 (1) Ensembl	Ensembl	6,269 nt	Select Tool ZFIN BLAST
mRNA	lin28a-208 (1) Ensembl	Ensembl	5,479 nt	Select Tool ZFIN BLAST
mRNA	lin28ab-202 (1) Ensembl	Ensembl	494 nt	Select Tool ZFIN BLAST
ncRNA	lin28a-005 (1) Ensembl	Ensembl	793 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:1132 pME-Lin28

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations