Gene
manba
- ID
- ZDB-GENE-040426-721
- Name
- mannosidase, beta A, lysosomal
- Symbol
- manba Nomenclature History
- Previous Names
-
- zgc:55493 (1)
- zgc:76896
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55493 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ko et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| beta-mannosidosis | Alliance | Mannosidosis, beta | 248510 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006102 | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich |
| Domain | IPR006103 | Glycoside hydrolase family 2, catalytic domain |
| Domain | IPR041447 | Mannosidase Ig/CBM-like domain |
| Domain | IPR041625 | Beta-mannosidase, Ig-fold domain |
| Family | IPR050887 | Beta-mannosidase glycosyl hydrolases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
| Homologous_superfamily | IPR036156 | Beta-Galactosidase/glucuronidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Beta-Galactosidase/glucuronidase domain superfamily | Beta-mannosidase glycosyl hydrolases | Beta-mannosidase, Ig-fold domain | Galactose-binding-like domain superfamily | Glycoside hydrolase family 2, catalytic domain | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich | Glycoside hydrolase superfamily | Immunoglobulin-like fold | Mannosidase Ig/CBM-like domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVY7
|
901 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available