Gene

med25

ID

ZDB-GENE-040426-2850

Name

mediator complex subunit 25

Symbol

med25 Nomenclature History

Previous Names

zgc:63555

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Involved in roof of mouth development. Predicted to localize to mediator complex and nuclear transcription factor complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2. Is expressed in head; post-vent region; and trunk. Orthologous to several human genes including MED25 (mediator complex subunit 25).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Nakamura et al., 2011

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With med25 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Basel-Vanagait-Smirin-Yosef syndrome	616449

Associated With med25 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR021394	Mediator complex, subunit Med25, PTOV domain
Domain	IPR021419	Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily
Homologous_superfamily	IPR038196	Mediator complex subunit 25, PTOV domain superfamily

Domain Details Per Protein

Protein	Length	Mediator complex subunit 25, PTOV domain superfamily	Mediator complex, subunit Med25, PTOV domain	Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A
UniProtKB:A0A8M2BBF9 InterPro	725
UniProtKB:F1R0J2 InterPro	701
UniProtKB:Q6PEH8 InterPro	701
UniProtKB:A0A8M3AQJ9 InterPro	648

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	med25-202 (1) Ensembl	Ensembl	1,954 nt	Select Tool
mRNA	med25-201 (1) Ensembl	Ensembl	2,722 nt	Select Tool
mRNA	med25-203 (1) Ensembl	Ensembl	730 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations