Gene
znf488
- ID
- ZDB-GENE-040426-2747
- Name
- zinc finger protein 488
- Symbol
- znf488 Nomenclature History
- Previous Names
-
- prdm8 (1)
- wu:fd12b11
- zgc:63680
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within spinal cord motor neuron cell fate specification. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; and neural tube. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to several human genes including ZNF488 (zinc finger protein 488).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137167 (19 images)
- IMAGE:7158686 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Scott et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR044402 | PRDM8-like, PR/SET domain |
| Family | IPR052296 | Transcriptional Repressor and Histone Methyltransferase |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | PRDM8-like, PR/SET domain | SET domain | SET domain superfamily | Transcriptional Repressor and Histone Methyltransferase | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A5Y1
|
502 | ||||||
|
UniProtKB:Q7SXY1
|
502 | ||||||
|
UniProtKB:A0AAB0H375
|
502 |
Interactions and Pathways
No data available
Plasmids
No data available