Gene
pgk1
- ID
- ZDB-GENE-040426-2711
- Name
- phosphoglycerate kinase 1
- Symbol
- pgk1 Nomenclature History
- Previous Names
-
- wu:fd59b07
- wu:fj36g06
- zgc:56252
- zgc:77899
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Acts upstream of or within several processes, including inner ear development; nervous system development; and positive regulation of oxidative phosphorylation. Predicted to be active in cytosol. Is expressed in cardiac ventricle; liver; nervous system; and somite. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to several human genes including PGK1 (phosphoglycerate kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| phosphoglycerate kinase 1 deficiency | Alliance | Phosphoglycerate kinase 1 deficiency | 300653 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Phosphoglycerate kinase | Phosphoglycerate kinase, conserved site | Phosphoglycerate kinase, N-terminal | Phosphoglycerate kinase superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZV29
|
417 |
Interactions and Pathways
No data available
Plasmids
No data available