Gene
gab1
- ID
- ZDB-GENE-040426-2674
- Name
- GRB2-associated binding protein 1
- Symbol
- gab1 Nomenclature History
- Previous Names
-
- fb11b01
- fc66d01
- wu:fb11b01
- wu:fc66d01
- zgc:56412 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity. Acts upstream of or within epiboly. Predicted to be active in cytoplasm. Is expressed in brain; heart; inner ear; and swim bladder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56412 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Yousaf et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 26 | Alliance | ?Deafness, autosomal recessive 26 | 605428 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GRB2-associated-binding protein 1-4-like | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9P5A1 | InterPro | 754 | |||
| UniProtKB:A0A8M6YVD8 | InterPro | 742 | |||
| UniProtKB:A0A8M6YUV9 | InterPro | 770 | |||
| UniProtKB:A0A8M9PTD5 | InterPro | 726 | |||
| UniProtKB:A0A8M9PWZ6 | InterPro | 667 | |||
| UniProtKB:F1Q7S5 | InterPro | 740 | |||
| UniProtKB:F6NTT0 | InterPro | 712 | |||
| UniProtKB:A0AB32TGR8 | InterPro | 637 |
Interactions and Pathways
No data available
Plasmids
No data available