Gene
lta4h
- ID
- ZDB-GENE-040426-2477
- Name
- leukotriene A4 hydrolase
- Symbol
- lta4h Nomenclature History
- Previous Names
-
- zgc:85809
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have epoxide hydrolase activity and leukotriene-A4 hydrolase activity. Involved in several processes, including epiboly involved in gastrulation with mouth forming second; neutrophil chemotaxis; and response to bacterium. Predicted to localize to nucleus. Is expressed in intestinal bulb; macrophage; and neutrophil. Orthologous to human LTA4H (leukotriene A4 hydrolase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148006 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014782 | Peptidase M1, membrane alanine aminopeptidase |
| Domain | IPR015211 | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal |
| Domain | IPR045357 | Aminopeptidase N-like , N-terminal domain |
| Domain | IPR049980 | Leukotriene A4 hydrolase-like, catalytic domain |
| Family | IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase |
| Family | IPR012777 | Leukotriene A4 hydrolase/leucine aminopeptidase |
| Family | IPR034015 | Aminopeptidase, leukotriene A4 hydrolase-like |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR027268 | Peptidase M4/M1, CTD superfamily |
| Homologous_superfamily | IPR038502 | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily |
| Homologous_superfamily | IPR042097 | Aminopeptidase N-like , N-terminal domain superfamliy |
Domain Details Per Protein
| Protein | Length | Aminopeptidase, leukotriene A4 hydrolase-like | Aminopeptidase N-like , N-terminal domain | Aminopeptidase N-like , N-terminal domain superfamliy | Armadillo-type fold | Leukotriene A4 hydrolase/leucine aminopeptidase | Leukotriene A4 hydrolase-like, catalytic domain | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily | Peptidase M1, membrane alanine aminopeptidase | Peptidase M4/M1, CTD superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NUX4
|
611 |
Interactions and Pathways
No data available
Plasmids
No data available