Gene
spred1
- ID
- ZDB-GENE-040426-2338
- Name
- sprouty related EVH1 domain containing 1
- Symbol
- spred1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase binding activity. Acts upstream of or within blood vessel morphogenesis; lymph vessel development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85707 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Legius syndrome | Alliance | Legius syndrome | 611431 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | c-Kit-binding domain | PH-like domain superfamily | SPRE, EVH1 domain | Sprouty | WH1/EVH1 domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6NV01
|
391 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spred1-201
(1)
|
Ensembl | 3,432 nt | ||
| mRNA |
spred1-202
(1)
|
Ensembl | 2,545 nt |
Interactions and Pathways
No data available
Plasmids