Gene

gnl2

ID

ZDB-GENE-040426-2317

Name

G protein nucleolar 2

Symbol

gnl2 Nomenclature History

Previous Names

wu:fc15c12
zgc:65800 (1)
zgc:77319

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have GTP binding activity. Involved in several processes, including cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to localize to nucleolus. Is expressed in several structures, including head; immature eye; midbrain; neural plate; and segmental plate. Orthologous to human GNL2 (G protein nucleolar 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907726 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnl2 Human Ortholog

No data available

Associated With gnl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006073	GTP binding domain
Domain	IPR012971	Nucleolar GTP-binding protein 2, N-terminal domain
Domain	IPR024929	Nucleolar GTP-binding protein 2, circularly permuted GTPase motif
Domain	IPR030378	Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Family	IPR050755	TRAFAC YlqF/YawG GTPases, Ribosome Maturation
Homologous_superfamily	IPR023179	GTP-binding protein, orthogonal bundle domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase