Gene

pck2

ID

ZDB-GENE-040426-2266

Name

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

Symbol

pck2 Nomenclature History

Previous Names

id:ibd5157
zgc:77867

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; gluconeogenesis; and monocarboxylic acid metabolic process. Predicted to localize to cytosol and mitochondrion. Is expressed in extension; intestinal bulb; liver; and yolk syncytial layer. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152622 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pck2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		PEPCK deficiency, mitochondrial	261650

Associated With pck2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018091	Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
Domain	IPR035077	Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
Domain	IPR035078	Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
Family	IPR008209	Phosphoenolpyruvate carboxykinase, GTP-utilising
Homologous_superfamily	IPR008210	Phosphoenolpyruvate carboxykinase, N-terminal
Homologous_superfamily	IPR013035	Phosphoenolpyruvate carboxykinase, C-terminal