Gene

spint1a

ID

ZDB-GENE-040426-2169

Name

serine peptidase inhibitor, Kunitz type 1 a

Symbol

spint1a Nomenclature History

Previous Names

hai1a (1)
spint1l
cb376 (1)
sb:cb376
serine protease inhibitor HGFAI (1)
zgc:64075

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase inhibitor activity. Involved in several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to localize to integral component of membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb376 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 42 figures from 13 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spint1a Human Ortholog

No data available

Associated With spint1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
psoriasis	spint1a^{hi2217Tg/hi2217Tg}; nz50Tg	standard conditions	Martínez-Navarro et al., 2020
psoriasis	spint1a^{hi2217Tg/hi2217Tg}	standard conditions	Martínez-Navarro et al., 2020
psoriasis	spint1a^{hi2217Tg/hi2217Tg}; nc1Tg	standard conditions	Martínez-Navarro et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR002223	Pancreatic trypsin inhibitor Kunitz domain
Domain	IPR011106	Seven cysteines, N-terminal
Domain	IPR013980	MANSC domain
Domain	IPR022409	PKD/Chitinase domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR035986	PKD domain superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Immunoglobulin-like fold	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	MANSC domain	Pancreatic trypsin inhibitor Kunitz domain	Pancreatic trypsin inhibitor Kunitz domain superfamily	PKD/Chitinase domain	PKD domain superfamily	Proteinase inhibitor I2, Kunitz, conserved site	Seven cysteines, N-terminal
UniProtKB:A0A2R8QCE4 InterPro	523
UniProtKB:Q7T363 InterPro	516
UniProtKB:A0A8M9P036 InterPro	506

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	spint1a-201 (1) Ensembl	Ensembl	2,343 nt	Select Tool ZFIN BLAST
mRNA	spint1a-202 (1) Ensembl	Ensembl	3,726 nt	Select Tool ZFIN BLAST
mRNA	spint1a-203 (1) Ensembl	Ensembl	3,651 nt	Select Tool ZFIN BLAST
mRNA	spint1a-204 (1) Ensembl	Ensembl	3,702 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations